Plasma S100A8/A9 correlates with blood neutrophil counts, traditional risk factors, and cardiovascular disease in middle-aged healthy individuals.

@article{Cotoi2014PlasmaSC,
  title={Plasma S100A8/A9 correlates with blood neutrophil counts, traditional risk factors, and cardiovascular disease in middle-aged healthy individuals.},
  author={Ovidiu Simion Cotoi and Pontus Dun{\'e}r and Nayoung Ko and Bo Hedblad and Jan Nilsson and Harry Bj{\"o}rkbacka and A Schiopu},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2014},
  volume={34 1},
  pages={202-10}
}
OBJECTIVE The S100 alarmins A8, A9, and A8/A9, secreted by activated neutrophils and monocytes/macrophages, are involved in the pathogenesis of various inflammatory diseases. S100A8/A9 has previously been linked to atherogenesis and cardiovascular (CV) disease. We investigated whether S100A8, A9, and A8/A9 correlate with carotid artery disease and CV risk in apparently healthy individuals. APPROACH AND RESULTS We measured baseline S100A8, A9, and A8/A9 in 664 individuals aged 63 to 68 years… CONTINUE READING
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