Plasma PTX3 protein levels inversely correlate with insulin secretion and obesity, whereas visceral adipose tissue PTX3 gene expression is increased in obesity.

@article{OsorioConles2011PlasmaPP,
  title={Plasma PTX3 protein levels inversely correlate with insulin secretion and obesity, whereas visceral adipose tissue PTX3 gene expression is increased in obesity.},
  author={Oscar Osorio-Conles and Maria Guitart and Matilde Rodriguez Chac{\'o}n and Elsa Maym{\'o}-Masip and Jos{\'e} Mar{\'i}a Moreno-Navarrete and Marta Montori-Grau and Silvia Naef and Jos{\'e} Fern{\'a}ndez-Real and J. Vendrell and Anna Maria G{\'o}mez-Foix},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={301 6},
  pages={E1254-61}
}
Plasma acutephase protein pentraxin 3 (PTX3) concentration is dysregulated in human obesity and metabolic syndrome. Here, we explore its relationship with insulin secretion and sensitivity, obesity markers, and adipose tissue PTX3 gene expression. Plasma PTX3 protein levels were analyzed in a cohort composed of 27 lean [body mass index (BMI) ≤ 25 kg/m(2)] and 48 overweight (BMI 25-30 kg/m(2)) men (cohort 1). In this cohort, plasma PTX3 was negatively correlated with fasting triglyceride levels… CONTINUE READING
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