Plasma Neuropeptide Y Concentrations in Combat Exposed Veterans: Relationship to Trauma Exposure, Recovery from PTSD, and Coping

@article{Yehuda2006PlasmaNY,
  title={Plasma Neuropeptide Y Concentrations in Combat Exposed Veterans: Relationship to Trauma Exposure, Recovery from PTSD, and Coping},
  author={Rachel Yehuda and Sarah R. Brand and Ren Kui Yang},
  journal={Biological Psychiatry},
  year={2006},
  volume={59},
  pages={660-663}
}
BACKGROUND There is emerging interest in examining the role of plasma neuropeptide Y (NPY) as a protective stress factor. METHODS To further investigate this possibility, plasma NPY was measured in 11 nonexposed veterans, 11 combat-exposed veterans without posttraumatic stress disorder (PTSD), and 12 veterans with current PTSD. RESULTS A significant group difference in plasma NPY (F(2,31) = 5.16, p = .012) was observed, reflecting higher NPY levels in exposed veterans without PTSD than in… Expand
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TLDR
Findings from preclinical and clinical studies of NPY that are of relevance to stress-associated syndromes and potential physiological contributions of the neuropeptide to the disorder are consolidated to suggest that reduced central nervous system NPY concentrations or function may be associated with PTSD. Expand
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TLDR
The results of cannot be compared with those of NPY in the central nervous system (CNS), but these findings might be due to the nature of depression and PTSD in accident survivors. Expand
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TLDR
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TLDR
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References

SHOWING 1-10 OF 22 REFERENCES
Plasma cortisol and neuropeptide Y in female victims of intimate partner violence
TLDR
The preliminary findings suggest that victims of IPV, like women traumatized by childhood abuse, may be characterized by alterations in hypothalamic-pituitary-adrenal axis functioning, however, further study is needed to identify specific stress system disturbances in this group. Expand
Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD
TLDR
This study suggests that combat stress-induced decreases in plasma NPY may mediate, in part, the noradrenergic system hyperreactivity observed in combat-related PTSD. Expand
Trauma exposure rather than posttraumatic stress disorder is associated with reduced baseline plasma neuropeptide-Y levels
TLDR
Trauma exposure rather than posttraumatic stress disorder is associated with reduced baseline plasma neuropeptide-Y levels, which is negatively associated with trauma exposure but not post traumatic stress disorder symptoms in active duty personnel. Expand
Plasma neuropeptide-Y concentrations in humans exposed to military survival training
TLDR
Assessment of plasma NPY immunoreactivity in healthy soldiers participating in high intensity military training at the U.S. Army survival school provides evidence that uncontrollable stress significantly increases NPY in humans, and when extended, produces a significant depletion of NPY. Expand
Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress: replication and extension of previous report
TLDR
These data replicate previous studies demonstrating that acute stress elicits NPY release and that this release is positively associated with cortisol and NE release and also replicate the previous finding that greater levels ofNPY release are associated with less psychologic distress suggesting that NPY confers anxiolytic activity. Expand
Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism.
TLDR
Levels of NPY-like immunoreactivity (NPY-LI) in the cerebrospinal fluid of medication-free subjects with treatment refractory unipolar depression are examined, supporting the notion that impaired NPY function could contribute to depressive illness. Expand
The NPY system in stress, anxiety and depression
  • M. Heilig
  • Medicine, Psychology
  • Neuropeptides
  • 2004
TLDR
Information is provided on several brain structures involved in mediating anti-stress actions of NPY, with the most extensive evidence available for amygdala and hippocampus, and some evidence for regions within the septum, and locus coeruleus. Expand
Early Life Stress Changes Concentrations of Neuropeptide Y and Corticotropin-releasing Hormone in Adult Rat Brain. Lithium Treatment Modifies These Changes
TLDR
It is suggested that early life stress has long-term effects on brain NPY with implications for the development of depression/vulnerability to stress, and that one therapeutic mechanism of action of lithium is to increase brainNPY. Expand
Protection and Damage from Acute and Chronic Stress: Allostasis and Allostatic Overload and Relevance to the Pathophysiology of Psychiatric Disorders
  • B. McEwen
  • Psychology, Medicine
  • Annals of the New York Academy of Sciences
  • 2004
TLDR
In animal models, neurons in the hippocampus and prefrontal cortex respond to repeated stress by showing atrophy, whereas neurons in amygdala show a growth response, yet these are not necessarily “damaged” and may be treatable with the right medications. Expand
Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models
TLDR
The results suggest that NPY exerts anxiolytic-like effects, and that these effects are mediated through an interaction with noradrenergic systems. Expand
...
1
2
3
...