Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141

@inproceedings{Hsu2015PlasmaMP,
  title={Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141},
  author={Jye-Lin Hsu and Dick J. H. van den Boomen and Peter Tomasec and Michael P Weekes and Robin Antrobus and Richard J Stanton and Eva Rů{\vc}kov{\'a} and Daniel Martyn Sugrue and Gavin S. Wilkie and Andrew J Davison and Gavin W G Wilkinson and Paul J Lehner},
  booktitle={PLoS pathogens},
  year={2015}
}
Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I degradation. A systematic proteomic study using Plasma Membrane Profiling revealed US2 was unique in downregulating additional cellular targets, including: five distinct integrin α-chains, CD112, the interleukin-12 receptor, PTPRJ and… CONTINUE READING

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Human cytomegalovirus UL 141 protein interacts with CELF 5 and affects viral DNA replication

FEI ZOU, LU ZHI-TAO, +3 authors ZHENG-RONG SUN
  • 2018
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