Plasma Membrane Mechanical Stress Activates TRPC5 Channels

@inproceedings{Shen2015PlasmaMM,
  title={Plasma Membrane Mechanical Stress Activates TRPC5 Channels},
  author={Bing Shen and Ching-on Wong and On-Chai Lau and Theodosia Woo and Suwen Bai and Yu Huang and Xiao-qiang Yao},
  booktitle={PloS one},
  year={2015}
}
Mechanical forces exerted on cells impose stress on the plasma membrane. Cells sense this stress and elicit a mechanoelectric transduction cascade that initiates compensatory mechanisms. Mechanosensitive ion channels in the plasma membrane are responsible for transducing the mechanical signals to electrical signals. However, the mechanisms underlying channel activation in response to mechanical stress remain incompletely understood. Transient Receptor Potential (TRP) channels serve essential… CONTINUE READING