Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly

@article{Jouvenet2006PlasmaMI,
  title={Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly},
  author={Nolwenn Jouvenet and Stuart J. D. Neil and Cameron D. Bess and Marc C. Johnson and Cesar A. Virgen and Sanford M Simon and Paul D Bieniasz},
  journal={PLoS Biology},
  year={2006},
  volume={4},
  pages={S13 - 20}
}
Recently proposed models that have gained wide acceptance posit that HIV-1 virion morphogenesis is initiated by targeting the major structural protein (Gag) to late endosomal membranes. Thereafter, late endosome-based secretory pathways are thought to deliver Gag or assembled virions to the plasma membrane (PM) and extracellular milieu. We present several findings that are inconsistent with this model. Specifically, we demonstrate that HIV-1 Gag is delivered to the PM, and virions are… CONTINUE READING
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