• DOI:10.1074/jbc.M114.574699
Corpus ID: 14187824

Plasma Membrane Cholesterol as a Regulator of Human and Rodent P2X7 Receptor Activation and Sensitization*

@article{Robinson2014PlasmaMC,
  title={Plasma Membrane Cholesterol as a Regulator of Human and Rodent P2X7 Receptor Activation and Sensitization*},
  author={Lucy E. Robinson and M. Shridar and P. Smith and R. Murrell-Lagnado},
  journal={The Journal of Biological Chemistry},
  year={2014},
  volume={289},
  pages={31983 - 31994}
}

Lucy E. Robinson, M. Shridar, +1 author R. Murrell-Lagnado

Published 2014

Biology, Medicine

The Journal of Biological Chemistry

Background: P2X7 receptors are important in inflammation and immunity, but excessive activation results in cell death. Results: Facilitation of P2X7 receptor currents and dilation of the pore are enhanced by cholesterol depletion and reduced by cholesterol loading. Conclusion: Plasma membrane cholesterol destabilizes the open and dilated states of the receptor pore. Significance: Targeting of P2X7 to cholesterol-rich lipid rafts may protect cells from death. P2X7 receptors are nonselective… CONTINUE READING

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