Plasma Membrane Cholesterol as a Regulator of Human and Rodent P2X7 Receptor Activation and Sensitization*

  title={Plasma Membrane Cholesterol as a Regulator of Human and Rodent P2X7 Receptor Activation and Sensitization*},
  author={Lucy E. Robinson and M. Shridar and P. Smith and R. Murrell-Lagnado},
  journal={The Journal of Biological Chemistry},
  pages={31983 - 31994}
  • Lucy E. Robinson, M. Shridar, +1 author R. Murrell-Lagnado
  • Published 2014
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Background: P2X7 receptors are important in inflammation and immunity, but excessive activation results in cell death. Results: Facilitation of P2X7 receptor currents and dilation of the pore are enhanced by cholesterol depletion and reduced by cholesterol loading. Conclusion: Plasma membrane cholesterol destabilizes the open and dilated states of the receptor pore. Significance: Targeting of P2X7 to cholesterol-rich lipid rafts may protect cells from death. P2X7 receptors are nonselective… CONTINUE READING
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