Plasma Levels of Ketamine and Two of Its Metabolites in Surgical Patients Using a Gas Chromatographic Mass Fragmentographic Assay

@article{Domino1982PlasmaLO,
  title={Plasma Levels of Ketamine and Two of Its Metabolites in Surgical Patients Using a Gas Chromatographic Mass Fragmentographic Assay},
  author={Edward F. Domino and Elem{\'e}r K. Zsigmond and Laurence E. Domino and Kenneth E. Domino and Sarla P. Kothary and Steven E. Dominof},
  journal={Anesthesia \& Analgesia},
  year={1982},
  volume={61},
  pages={87–92}
}
Ketamine and two of its metabolites were determined up to 24 hours by a sensitive and specific gas chromatographic mass fragmentographic (GCMF) assay in the plasma of seven premedicated surgical patients. Each patient received ketamine in a dose between 2.0 and 2.2 mg/kg given intravenously over a 30-second period. Plasma levels of ketamine varied from 9,000 to 25,800 ng/ml 1 minute after injection to approximately 1,000 ng/ml when the patients began to recover consciousness. Within the next 24… Expand
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