Plasma Kinetics, Metabolism, and Urinary Excretion of Alpha‐Lipoic Acid following Oral Administration in Healthy Volunteers

@article{Teichert2003PlasmaKM,
  title={Plasma Kinetics, Metabolism, and Urinary Excretion of Alpha‐Lipoic Acid following Oral Administration in Healthy Volunteers},
  author={Jens Teichert and Robert Hermann and Peter Ruus and Rainer Preiss},
  journal={The Journal of Clinical Pharmacology},
  year={2003},
  volume={43}
}
R(+)‐alpha‐lipoic acid is a natural occurring compound that acts as an essential cofactor for certain dehydrogenase complexes. The redox couple alpha‐lipoic acid/dihydrolipoic acid possesses potent antioxidant activity. Exogenous racemic alpha‐lipoic acid orally administered for the symptomatic treatment of diabetic polyneuropathy is readily and nearly completely absorbed, with a limited absolute bioavailability of about 30% caused by high hepatic extraction. Although the pharmacokinetics of… 
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