Plasma HIV-1 RNA detection below 50 copies/ml and risk of virologic rebound in patients receiving highly active antiretroviral therapy.

@article{Doyle2012PlasmaHR,
  title={Plasma HIV-1 RNA detection below 50 copies/ml and risk of virologic rebound in patients receiving highly active antiretroviral therapy.},
  author={Tomas Doyle and Colette Joanne Smith and Paola Vitiello and Valentina Cambiano and Margaret Johnson and Andrew Owen and Andrew N Phillips and Anna Mar{\'i}a Geretti},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2012},
  volume={54 5},
  pages={724-32}
}
BACKGROUND Plasma human immunodeficiency virus type 1 (HIV-1) RNA suppression <50 copies/mL is regarded as the optimal outcome of highly active antiretroviral therapy (HAART). Current viral load (VL) assays show increased sensitivity, but the significance of RNA detection <50 copies/mL is unclear. METHODS This study investigated the virologic outcomes of 1247 patients with VL <50 copies/mL at an arbitrary time point during HAART (= T0), according to whether the actual, unreported (T0)VL was… CONTINUE READING
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Comparative evaluation of the ExaVirTM Load version 3 reverse transcriptase assay for the measurement of HIV-1 plasma viral load

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