Plasma HER2 amplification in cell-free DNA during neoadjuvant chemotherapy in breast cancer

@article{Bechmann2013PlasmaHA,
  title={Plasma HER2 amplification in cell-free DNA during neoadjuvant chemotherapy in breast cancer},
  author={Troels Bechmann and Rikke Fredslund Andersen and Niels Pallisgaard and Jonna Skov Madsen and Else Maae and Erik Hugger Jakobsen and Anne Marie Bak Jylling and Karina Dahl Steffensen and A. Vinther Jakobsen},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2013},
  volume={139},
  pages={995-1003}
}
Measurement of human epidermal growth factor receptor 2 (HER2) gene amplification in cell-free DNA (cfDNA) is an evolving technique in breast cancer, enabling liquid biopsies and treatment monitoring. The present study investigated the dynamics of plasma HER2 gene copy number and amplification in cfDNA during neoadjuvant chemotherapy. The study included 50 patients from a prospective cohort analyzed during neoadjuvant chemotherapy. Fifty healthy women with no history of cancer served as control… CONTINUE READING
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