Plasma Efavirenz Exposure, Sex, and Age Predict Virological Response in HIV-Infected African Children

@inproceedings{Bieczak2016PlasmaEE,
  title={Plasma Efavirenz Exposure, Sex, and Age Predict Virological Response in HIV-Infected African Children},
  author={Andrzej M Bieńczak and Paolo Denti and Adrian Cook and Lubbe Wiesner and Veronica Mulenga and Cissy M. Kityo and Addy Kekitiinwa and Diana M Gibb and David M Burger and A Sarah Walker and Helen Margaret McIlleron},
  booktitle={Journal of acquired immune deficiency syndromes},
  year={2016}
}
BACKGROUND Owing to insufficient evidence in children, target plasma concentrations of efavirenz are based on studies in adults. Our analysis aimed to evaluate the pediatric therapeutic thresholds and characterize the determinants of virological suppression in African children. METHODS We analyzed data from 128 African children (aged 1.7-13.5 years… CONTINUE READING