Plasma ET-1 Concentrations are Elevated in Patients with Hypertension - Meta-Analysis of Clinical Studies.

@article{Xu2017PlasmaEC,
  title={Plasma ET-1 Concentrations are Elevated in Patients with Hypertension - Meta-Analysis of Clinical Studies.},
  author={Mei Xu and Yong-Ping Lu and Ahmed Abdallah Hasan and Berthold Hocher},
  journal={Kidney & blood pressure research},
  year={2017},
  volume={42 2},
  pages={
          304-313
        }
}
BACKGROUND/AIMS A recent study revealed that global overexpression of ET-1 causes a slight reduction in systemic blood pressure. Moreover, heterozygous ET-1 knockout mice are hypertensive. The role of ET-1 in human hypertension was so far not addressed by a strict meta-analysis of published human clinical studies. METHODS We included studies published between January 1, 1990 and February 28, 2017. We included case control studies analyzing untreated essential hypertension or hypertensive… CONTINUE READING