Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.

@article{Sun2015PlasmaDT,
  title={Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.},
  author={Kun Sun and Peiyong Jiang and K. C. Allen Chan and J H M Wong and Yvonne Kwun Yue Cheng and Raymond H. S. Liang and Wai-kong Chan and Edmond S. K. Ma and Stephen L Chan and Suk Hang Cheng and Rebecca Wing Yan Chan and Yu Kwan Tong and Simon S. M. Ng and Raymond S M Wong and David S. C. Hui and Tse Ngong Leung and Tak Yeung Leung and Paul B. S. Lai and Rossa W. K. Chiu and Yuk Ming Dennis Lo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 40},
  pages={E5503-12}
}
Plasma consists of DNA released from multiple tissues within the body. Using genome-wide bisulfite sequencing of plasma DNA and deconvolution of the sequencing data with reference to methylation profiles of different tissues, we developed a general approach for studying the major tissue contributors to the circulating DNA pool. We tested this method in pregnant women, patients with hepatocellular carcinoma, and subjects following bone marrow and liver transplantation. In most subjects, white… CONTINUE READING
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