Plasma D-dimer for the diagnosis of thromboembolic disorders in dogs.

@article{Stokol2003PlasmaDF,
  title={Plasma D-dimer for the diagnosis of thromboembolic disorders in dogs.},
  author={Tracy Stokol},
  journal={The Veterinary clinics of North America. Small animal practice},
  year={2003},
  volume={33 6},
  pages={
          1419-35
        }
}
  • Tracy Stokol
  • Published 2003 in
    The Veterinary clinics of North America. Small…
D-dimer is formed during thrombus formation when factor XIIIa crosslinks the terminal D-domains of fibrin. The D-dimer epitope is exposed when the thrombus is lysed by plasmin. Thus, D-dimer represents both thrombin and plasmin activation and is specific for fibrinolysis. D-dimer concentrations are increased in dogs with DIC or other thromboembolic disorders, but because D-dimer is an indicator of physiologic or pathologic fibrinolysis, values are elevated in other conditions associated with… CONTINUE READING