Plasma (1→3)-β-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes

@article{Obayashi1995PlasmaM,
  title={Plasma (1→3)-β-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes},
  author={Taminori Obayashi and Toru Kawai and Makiko Yoshida and Tatsuya Mori and Hiromichi Yamaguchi},
  journal={The Lancet},
  year={1995},
  volume={345},
  pages={17-20}
}
(1-->3)-beta-D-glucan is a characteristic fungal cell-wall constituent. To assess the clinical usefulness of this glucan in screening for invasive fungal infection or fungal febrile episodes, we measured the plasma concentration at the time of routine blood culture in 202 febrile episodes by means of factor G, a horseshoe-crab coagulation enzyme that is extremely sensitive to this polysaccharide. With a plasma cut-off value of 20 pg/mL, 37 of 41 episodes of definite fungal infections (confirmed… CONTINUE READING

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