Plaques of Alzheimer's disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete.
@article{Macdonald2006PlaquesOA,
title={Plaques of Alzheimer's disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete.},
author={Alan B. Macdonald},
journal={Medical hypotheses},
year={2006},
volume={67 3},
pages={
592-600
}
}Figures from this paper
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References
SHOWING 1-10 OF 25 REFERENCES
Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes
- BiologyNeurobiology of Aging
- 2006
Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease.
- Biology, MedicineJournal of Alzheimer's disease : JAD
- 2004
The data indicate that Borrelia burgdorferi may persist in the brain and be associated with amyloid plaques in AD, and suggest that these spirochetes, perhaps in an analogous fashion to Treponema pallidum, may contribute to dementia, cortical atrophy and amyloids deposition.
Alzheimer's disease—a spirochetosis?
- Biology, MedicineNeuroreport
- 1993
Observations that in 14 autopsy cases with histopathologically confirmed AD, spirochetes were found in blood and cerebrospinal fluid and, moreover, could be isolated from brain tissue suggest that spiroChetes may be one of the causes of AD and that they may be the source of the β amyloid deposited in the AD brain.
Borrelia in the brains of patients dying with dementia.
- MedicineJAMA
- 1986
Indirect immunofluorescence, using monoclonal antibodies specific for Borrelia species, resulted in fluorescence of spirochetes that had previously been identified by darkfield microscope examination of autopsy brain tissues from two patients with dementia.
Concurrent neocortical borreliosis and Alzheimer's disease.
- Medicine, PsychologyHuman pathology
- 1987
The Significance of Measles Virus Antigen and Genome Distribution in the CNS in SSPE for Mechanisms of Viral Spread and Demyelination
- Biology, MedicineJournal of neuropathology and experimental neurology
- 1996
The relationship between myelin destruction and oligodendrocytic infection suggested that the demyelination may be solely the result of virus infection, and findings may suggest viral spread in a cephalo-caudal direction, probably by transneuronal spread.
Rabies: interactions between neurons and viruses. A review of the history of Negri inclusion bodies
- BiologyNeuropathology and applied neurobiology
- 1996
The first clear-cut description of a virus-nerve cell interaction was made by Adelchi Negri in 1903 with the detection of cytoplasmic bodies (Negri bodies) in subsets of neurons in the brain from…
Clonal expansion of hypermutated measles virus in a SSPE brain.
- BiologyVirology
- 1993
Despite the presence of MV variants with genes encoding the intact matrix protein open reading frame, M protein could not be detected in any of the brain regions.
Transfection "Junk" DNA - a link to the pathogenesis of Alzheimer's disease?
- BiologyMedical hypotheses
- 2006
P3-197 Cystic borrelia in Alzheimer’s disease and in non-dementia neuroborreliosis
- Biology, MedicineAlzheimer's & Dementia
- 2006