Plaque-prone hemodynamics impair endothelial function in pig carotid arteries.
@article{Gambillara2006PlaqueproneHI,
title={Plaque-prone hemodynamics impair endothelial function in pig carotid arteries.},
author={Veronica Gambillara and C{\'e}line Chambaz and Gabriela Montorzi and Sylvain Roy and Nikos Stergiopulos and Paolo Silacci},
journal={American journal of physiology. Heart and circulatory physiology},
year={2006},
volume={290 6},
pages={
H2320-8
}
}Hemodynamic forces play an active role in vascular pathologies, particularly in relation to the localization of atherosclerotic lesions. It has been established that low shear stress combined with cyclic reversal of flow direction (oscillatory shear stress) affects the endothelial cells and may lead to an initiation of plaque development. The aim of the study was to analyze the effect of hemodynamic conditions in arterial segments perfused in vitro in the absence of other stimuli. Left common…
106 Citations
Oscillatory shear stress and reduced compliance impair vascular functions.
- Biology, EngineeringClinical hemorheology and microcirculation
- 2007
It is shown that both plaque-prone shear stress and reduced compliance trigger endothelial dysfunction, but via different mechanisms, and only reduced compliance affected vascular contractility, inducing a dedifferentiation of smooth muscle cells and a consequent loss of norepinephrine sensitivity.
Ex vivo and in vivo regulation of arginase in response to wall shear stress
- Biology
- 2010
Ex vivo perfusion showed that exposure of carotid segments to both low and oscillatory flow conditions significantly increase arginase II protein expression and activity as compared to high shear stress athero-protective flow condition.
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives.
- Biology, MedicinePhysiological reviews
- 2011
Current knowledge on the role of disturbed flow in EC physiology and pathophysiology, as well as its clinical implications are summarized to contribute to the understanding of the etiology of lesion development in vascular niches with disturbed flow and help to generate new approaches for therapeutic interventions.
Impact of Aging on Conduit Artery Retrograde and Oscillatory Shear at Rest and During Exercise: Role of Nitric Oxide
- BiologyHypertension
- 2011
It is demonstrated for the first time that reduced NO bioavailability in the resistance vessels contributes, in part, to age-related discrepancies in resting shear patterns, thus identifying a potential mechanism for increased risk of atherosclerotic disease in conduit arteries.
Reduced cyclic stretch, endothelial dysfunction, and oxidative stress: an ex vivo model.
- Biology, MedicineCardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
- 2010
Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE-/- mice.
- BiologyAtherosclerosis
- 2013
Blood pressure regulation VIII: resistance vessel tone and implications for a pro-atherogenic conduit artery endothelial cell phenotype
- Biology, MedicineEuropean Journal of Applied Physiology
- 2013
A vast amount of evidence supports the notion that excessive blood pressure and oscillatory shear stress are potent pro-atherogenic signals to the endothelium, and set the stage for a new paradigm concerning the mechanistic link between increased microvascular tone and development of conduit artery endothelial dysfunction and thus increased risk for peripheral artery disease.
Disturbed Blood Flow Acutely Induces Activation and Apoptosis of the Human Vascular Endothelium
- Biology, MedicineHypertension
- 2013
Findings indicate that disturbed blood flow acutely induces endothelial activation and apoptosis in humans, as reflected by release of microparticles from activated (CD62E+) and apoptotic (CD31+/CD42b–) endothelial cells.
Impact of Age and Body Position on the Contribution of Nitric Oxide to Femoral Artery Shear Rate: Implications for Atherosclerosis
- Medicine, BiologyHypertension
- 2014
Overall, this study reveals that age-related reductions in mean shear rate are largely explained by reductions in antegrade shear as a result of reduced NO bioavailability in the elderly.
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