Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein.

@article{Yang2000PlaqueassociatedA,
  title={Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein.},
  author={Fusheng Yang and Kunihiro Ueda and Pei-Jer Chen and K. Ashe and Gregory M. Cole},
  journal={Brain research},
  year={2000},
  volume={853 2},
  pages={381-3}
}
Patients with the Lewy body variant (LBV) of Alzheimer's disease (AD) have ubiquitinated intraneuronal and neuritic accumulations of alpha-synuclein and show less neuron loss and tau pathology than other AD patients. Aged Tg2576 transgenic mice overexpressing human betaAPP695. KM670/671NL have limited neuron loss and tau pathology, but frequent ubiquitin- and alpha-synuclein-positive, tau-negative neurites resembling those seen in the LBV of AD. 

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