Plants utilize a highly conserved system for repair of NADH and NADPH hydrates.

@article{Niehaus2014PlantsUA,
  title={Plants utilize a highly conserved system for repair of NADH and NADPH hydrates.},
  author={Tom D Niehaus and Lynn G L Richardson and Satinder K Gidda and Mona Elbadawi-Sidhu and John K. Meissen and Robert T Mullen and Oliver Fiehn and Andrew D. Hanson},
  journal={Plant physiology},
  year={2014},
  volume={165 1},
  pages={52-61}
}
NADH and NADPH undergo spontaneous and enzymatic reactions that produce R and S forms of NAD(P)H hydrates [NAD(P)HX], which are not electron donors and inhibit various dehydrogenases. In bacteria, yeast (Saccharomyces cerevisiae), and mammals, these hydrates are repaired by the tandem action of an ADP- or ATP-dependent dehydratase that converts (S)-NAD(P)HX to NAD(P)H and an epimerase that facilitates interconversion of the R and S forms. Plants have homologs of both enzymes, the epimerase… CONTINUE READING
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