BACKGROUND Treatment of plantar warts caused by human papilloma virus (HPV) strain types 1, 2 and 4 is often difficult and a challenging problem. Various therapeutic modalities available for treating this problem have not been uniformly successful. PURPOSE The purpose of present study is to evaluate the efficacy of adapalene applied locally with occlusion in plantar warts. MATERIALS AND METHODS A total of 10 patient with 118 plantar warts were included in an open study. All were treated by applying adapalene gel 0.1% after paring of warts if needed followed by occlusive dressing with polythene paper in each patient. The effects of the treatment were evaluated every week till the clearance of all warts. FINDINGS Adapalene was used in 10 patient having 118 plantar warts. All the warts cleared in 39±15.07 days. There was no side effects like scar formation, irritation, erythema or infection with adapalene. CONCLUSION Adapalene clears the plantar warts faster compared to other modalities available. LIMITATION Need trial with large number of patients.