Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy.

@article{Khan2010PlantTK,
  title={Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy.},
  author={Zahidul Khan and Wolfgang Knecht and Mette Willer and Elżbieta Rozpędowska and Peter Kristoffersen and Anders R Clausen and Birgitte Munch-Petersen and Per Almqvist and Zoran Gojkovi{\'c} and Jure Pi{\vs}kur and Tomas J. Ekstr{\"o}m},
  journal={Neuro-oncology},
  year={2010},
  volume={12 6},
  pages={549-58}
}
The prognosis for malignant gliomas remains poor, and new treatments are urgently needed. Targeted suicide gene therapy exploits the enzymatic conversion of a prodrug, such as a nucleoside analog, into a cytotoxic compound. Although this therapeutic strategy has been considered a promising regimen for central nervous system (CNS) tumors, several obstacles have been encountered such as inefficient gene transfer to the tumor cells, limited prodrug penetration into the CNS, and inefficient… CONTINUE READING
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