Plant proteolytic enzyme papain abrogates angiogenic activation of human umbilical vein endothelial cells (HUVEC) in vitro

@article{Mohr2013PlantPE,
  title={Plant proteolytic enzyme papain abrogates angiogenic activation of human umbilical vein endothelial cells (HUVEC) in vitro},
  author={Thomas Mohr and Lucia Desser},
  journal={BMC Complementary and Alternative Medicine},
  year={2013},
  volume={13},
  pages={231 - 231}
}
  • Thomas Mohr, Lucia Desser
  • Published 2013
  • Medicine
  • BMC Complementary and Alternative Medicine
  • BackgroundVascular endothelial growth factor (VEGF) is a key regulator of physiologic and pathogenic angiogenesis in diseases such as cancer and diabetic retinopathy. It is known that cysteine proteases from plants, like bromelain and papain are capable to suppress inflammatory activation. Recent studies have demonstrated that they may interfere with angiogenesis related pathways as well. The aim of this study was to investigate the anti-angiogenic effects of papain on human umbilical vein… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 15 CITATIONS

    Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 42 REFERENCES

    Pro-inflammatory angiogenesis is mediated by p38 MAP kinase.

    VIEW 1 EXCERPT

    p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability.

    VIEW 12 EXCERPTS
    HIGHLY INFLUENTIAL

    Signaling angiogenesis via p42/p44 MAP kinase and hypoxia.

    VIEW 1 EXCERPT