Plant lectins are novel Toll-like receptor agonists.

  title={Plant lectins are novel Toll-like receptor agonists.},
  author={John F. Unitt and David C. Hornigold},
  journal={Biochemical pharmacology},
  volume={81 11},
The T cell mitogen and plant glycoprotein, phytohaemagglutinin (PHA), is commonly used to stimulate peripheral blood mononuclear cell (PBMC) preparations to produce IL-2, IL-5, GM-CSF and IFN-γ and so provide an assay to detect immunosuppressants like FK506 and anti-inflammatories such as PDE IV inhibitors. During the early discovery of novel TLR agonists for the treatment of asthma we initially showed that PHA-L is a specific human TLR4 agonist, devoid of effects on equivalent TLR4 null cells… CONTINUE READING
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