Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes.

@article{Sawai2006PlantLS,
  title={Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes.},
  author={Satoru Sawai and Tomoyoshi Akashi and Nozomu Sakurai and Hideyuki Suzuki and Daisuke Shibata and Shin-ichi Ayabe and Toshio Aoki},
  journal={Plant & cell physiology},
  year={2006},
  volume={47 5},
  pages={673-7}
}
Sterols, essential eukaryotic constituents, are biosynthesized through either cyclic triterpenes, lanosterol (fungi and animals) or cycloartenol (plants). The cDNA for OSC7 of Lotus japonicus was shown to encode lanosterol synthase (LAS) by the complementation of a LAS-deficient mutant yeast and structural identification of the accumulated lanosterol. A double site-directed mutant of OSC7, in which amino acid residues crucial for the reaction specificity were changed to the cycloartenol… CONTINUE READING

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