Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.

@article{Kaur2008PlantFA,
  title={Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.},
  author={Parminder Jeet Kaur and Sanjeev Shukla and Sanjay Gupta},
  journal={Carcinogenesis},
  year={2008},
  volume={29 11},
  pages={
          2210-7
        }
}
Inappropriate activation of phosphatidylinositol 3-kinase-Akt signaling contributes to the development of several human malignancies. Modulation of Akt activity is a strategy that may be valuable in chemopreventive and chemotherapeutic regimens. We have previously demonstrated that apigenin, a plant flavone, causes decreased survival in human prostate cancer cells. However, the molecular mechanism underlying this observation remains elusive. In the present study, we investigated the mechanisms… CONTINUE READING
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