Plant-derived mouse IgG monoclonal antibody fused to KDEL endoplasmic reticulum-retention signal is N-glycosylated homogeneously throughout the plant with mostly high-mannose-type N-glycans.

@article{Triguero2005PlantderivedMI,
  title={Plant-derived mouse IgG monoclonal antibody fused to KDEL endoplasmic reticulum-retention signal is N-glycosylated homogeneously throughout the plant with mostly high-mannose-type N-glycans.},
  author={Ada Triguero and Gleysin Cabrera and Jose A. Cremata and C Sw Yuen and Jun X. Wheeler and Nadia I Ram{\'i}rez},
  journal={Plant biotechnology journal},
  year={2005},
  volume={3 4},
  pages={449-57}
}
Plants are potential hosts for the expression of recombinant glycoproteins intended for therapeutic purposes. However, N-glycans of mammalian glycoproteins produced in transgenic plants differ from their natural counterparts. The use of the endoplasmic reticulum (ER)-retention signal has been proposed to restrict glycosylation of plantibodies to only high… CONTINUE READING