Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells.

@article{Le2003Plantderived3I,
  title={Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells.},
  author={Hien Thu Le and Charlene M Schaldach and Gary L. Firestone and Leonard F. Bjeldanes},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 23},
  pages={21136-45}
}
3,3'-Diindolylmethane (DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. Our results indicate that DIM exhibits potent antiproliferative and antiandrogenic properties in androgen-dependent human prostate cancer cells. DIM suppresses cell proliferation of LNCaP cells and inhibits dihydrotestosterone (DHT) stimulation of DNA synthesis. These activities were not produced in androgen-independent PC-3 cells. Moreover, DIM inhibited… CONTINUE READING
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Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy.

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