Plant cytokinin analogues with inhibitory activity on cyclin-dependent kinases exert their antiproliferative effect through induction of apoptosis initiated by the mitochondrial pathway: determination by a multiparametric flow cytometric analysis.

Abstract

OBJECTIVE Regulation of the cell cycle by cyclin-dependent kinase (CDK) activity occurs at multiple levels and is often altered in human cancers. Therefore, CDK activity has been targeted for drug discovery, and a number of small molecules have now been identified as CDK inhibitors. Plant cytokinin analogues with CDK inhibitory activity and… (More)

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@article{Vermeulen2002PlantCA, title={Plant cytokinin analogues with inhibitory activity on cyclin-dependent kinases exert their antiproliferative effect through induction of apoptosis initiated by the mitochondrial pathway: determination by a multiparametric flow cytometric analysis.}, author={Katrien Vermeulen and Miroslav Strnad and Libor Havl{\'i}cek and Harry A Van Onckelen and Marc Lenjou and Griet Nijs and Dirk R van Bockstaele and Zwi Nisan Berneman}, journal={Experimental hematology}, year={2002}, volume={30 10}, pages={1107-14} }