Plant anticancer agents XLIV. Cytotoxic constituents from Stizophyllum riparium.


Bioactivity-guided fractionation of a CHCl3 extract of Stizophyllum riparium has afforded six new compounds, namely, the triterpene esters, 3 beta-hydroxy-24-transferulyloxyurs-12-en-28-oic acid, 3 beta-hydroxy-24-cis-ferulyloxyurs-12-en-28-oic acid, 3 beta, 19-dihydroxy-24-trans-ferulyloxyurs-12-en-28-oic acid, and the pregnane derivatives, 2 alpha, 3 beta, 12 beta-trihydroxypregna-4,7,16-trien-20-one, 2 alpha, 3 beta, 12 beta-trihydroxypregna-4,7-dien-20-one, and 16 alpha-methoxy-2 alpha, 3 beta, 12 beta-trihydroxypregna-4,7-dien-20-one. The structures of these isolates were established by spectroscopic and chemical methods. Compounds 1, 2, and 4 exhibited cytotoxic activity against the P-388 lymphocytic leukemia test system in cell culture.

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@article{Duh1987PlantAA, title={Plant anticancer agents XLIV. Cytotoxic constituents from Stizophyllum riparium.}, author={Chang-Yih Duh and John M . Pezzuto and A Douglas Kinghorn and Sze Lee Leung and N. R. Farnsworth}, journal={Journal of natural products}, year={1987}, volume={50 1}, pages={63-74} }