Planktocyclin, a cyclooctapeptide protease inhibitor produced by the freshwater cyanobacterium Planktothrix rubescens.

@article{Baumann2007PlanktocyclinAC,
  title={Planktocyclin, a cyclooctapeptide protease inhibitor produced by the freshwater cyanobacterium Planktothrix rubescens.},
  author={Heike I. Baumann and Simone Keller and Falko E Wolter and Graeme J. Nicholson and Guenther Jung and Roderich D S{\"u}ssmuth and Friedrich J{\"u}ttner},
  journal={Journal of natural products},
  year={2007},
  volume={70 10},
  pages={1611-5}
}
The freshwater cyanobacterium Planktothrix rubescens produces the cyclooctapeptide cyclo(Pro-Gly-Leu-Val-Met-Phe-Gly-Val). The chemical structure is new. This homodetic cyclic octapeptide was named planktocyclin ( 1). It consists solely of proteinogenic l-amino acids and is a strong inhibitor of mammalian trypsin and alpha-chymotrypsin and a moderately active inhibitor of human recombinant caspase-8. Mass spectrometric and 2D-NMR spectroscopic data allowed the determination of its structure… CONTINUE READING

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