Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling.

@article{Oviedo2008PlanarianPH,
  title={Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling.},
  author={N{\'e}stor J Oviedo and Bret J Pearson and Michael Levin and Alejandro S{\'a}nchez Alvarado},
  journal={Disease models & mechanisms},
  year={2008},
  volume={1 2-3},
  pages={131-43; discussion 141}
}
We have identified two genes, Smed-PTEN-1 and Smed-PTEN-2, capable of regulating stem cell function in the planarian Schmidtea mediterranea. Both genes encode proteins homologous to the mammalian tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN). Inactivation of Smed-PTEN-1 and -2 by RNA interference (RNAi) in planarians disrupts regeneration, and leads to abnormal outgrowths in both cut and uncut animals followed soon after by death (lysis). The resulting… CONTINUE READING
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