Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling.

  title={Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling.},
  author={N{\'e}stor J Oviedo and Bret J Pearson and Michael Levin and Alejandro S{\'a}nchez Alvarado},
  journal={Disease models & mechanisms},
  volume={1 2-3},
  pages={131-43; discussion 141}
We have identified two genes, Smed-PTEN-1 and Smed-PTEN-2, capable of regulating stem cell function in the planarian Schmidtea mediterranea. Both genes encode proteins homologous to the mammalian tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN). Inactivation of Smed-PTEN-1 and -2 by RNA interference (RNAi) in planarians disrupts regeneration, and leads to abnormal outgrowths in both cut and uncut animals followed soon after by death (lysis). The resulting… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 41 extracted citations

An insulin-like peptide regulates size and adult stem cells in planarians.

The International journal of developmental biology • 2012
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 63 references

PTEN: from pathology to biology.

Trends in cell biology • 2003
View 14 Excerpts
Highly Influenced

Cancer, type 2 diabetes, and ageing: news from flies and worms.

Swiss medical weekly • 2004
View 10 Excerpts
Highly Influenced

PTENless means more.

View 13 Excerpts
Highly Influenced

The C

S. Ogg, G. Ruvkun
elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell 2, 887-893. • 1998
View 4 Excerpts
Highly Influenced

Planarians as a model system for in vitro teratogenesis studies.

Teratogenesis, carcinogenesis, and mutagenesis • 1982
View 4 Excerpts
Highly Influenced

Molecular biology

J. Marx
Cancer’s perpetual source? Science 317, 10291031. • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…