Planar cell polarity signalling couples cell division and morphogenesis during neurulation

@article{Ciruna2006PlanarCP,
  title={Planar cell polarity signalling couples cell division and morphogenesis during neurulation},
  author={Brian Ciruna and Andreas Jenny and Diana L. Lee and Marek Mlodzik and Alexander F Schier},
  journal={Nature},
  year={2006},
  volume={439},
  pages={220-224}
}
Environmental and genetic aberrations lead to neural tube closure defects (NTDs) in 1 out of every 1,000 births. Mouse and frog models for these birth defects have indicated that Van Gogh-like 2 (Vangl2, also known as Strabismus) and other components of planar cell polarity (PCP) signalling might control neurulation by promoting the convergence of neural progenitors to the midline. Here we show a novel role for PCP signalling during neurulation in zebrafish. We demonstrate that non-canonical… CONTINUE READING
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polarity in the Drosophila eye

  • H. W. van Straaten, A. J. Copp
  • 2005

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