Planar cell polarity signaling: the developing cell's compass.

  title={Planar cell polarity signaling: the developing cell's compass.},
  author={Eszter K Vladar and Dragana Antic and Jeffrey D. Axelrod},
  journal={Cold Spring Harbor perspectives in biology},
  volume={1 3},
Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue gradients to subcellular asymmetry, whereas a downstream system amplifies subcellular asymmetry and communicates polarity between cells. In this review, we discuss apparent similarities and differences… CONTINUE READING

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