Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation.

@article{Dohn2013PlanarCP,
  title={Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation.},
  author={Michael Robert Dohn and Nathan A Mundell and Leah M Sawyer and Julie A Dunlap and Jason R. Jessen},
  journal={Developmental biology},
  year={2013},
  volume={383 1},
  pages={39-51}
}
Zebrafish gastrulation cell movements occur in the context of dynamic changes in extracellular matrix (ECM) organization and require the concerted action of planar cell polarity (PCP) proteins that regulate cell elongation and mediolateral alignment. Data obtained using Xenopus laevis gastrulae have shown that integrin-fibronectin interactions underlie the formation of polarized cell protrusions necessary for PCP and have implicated PCP proteins themselves as regulators of ECM. By contrast, the… CONTINUE READING
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