Planar cell polarity genes and neural tube closure.

  title={Planar cell polarity genes and neural tube closure.},
  author={Naoto Ueno and Nicholas D. E. Greene},
  journal={Birth defects research. Part C, Embryo today : reviews},
  volume={69 4},
Closure of the neural tube is essential for normal development of the brain and spinal cord. Failure of closure results in neural tube defects (NTDs), common and clinically severe congenital malformations whose molecular mechanisms remain poorly understood. On the other hand, it is increasingly well established that common molecular mechanisms are employed to regulate morphogenesis of multicellular organisms. For example, signaling triggered by polypeptide growth factors is highly conserved… CONTINUE READING