Planar and vertical signals control cellular differentiation and patterning in the mammalian cochlea.

@article{Montcouquiol2003PlanarAV,
  title={Planar and vertical signals control cellular differentiation and patterning in the mammalian cochlea.},
  author={Mireille Montcouquiol and Matthew William Kelley},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 28},
  pages={9469-78}
}
The sensory epithelium of the mammalian cochlea is composed of a regular mosaic of sensory hair cells and nonsensory supporting cells. During development, differentiation occurs in a gradient that progresses along the axis of the cochlea from base to apex. To begin to identify some of the factors that regulate this developmental process, the potential roles of planar and vertical signals were examined during early stages of cochlear development. We demonstrate roles for both underlying… CONTINUE READING
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