Planar Cell Polarity Genes Regulate Polarized Extracellular Matrix Deposition during Frog Gastrulation

@article{Goto2005PlanarCP,
  title={Planar Cell Polarity Genes Regulate Polarized Extracellular Matrix Deposition during Frog Gastrulation},
  author={Toshiyasu Goto and Lance A Davidson and Makoto Asashima and Ray Keller},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={787-793}
}
The noncanonical wnt/planar cell polarity (PCP) pathway [1] regulates the mediolaterally (planarly) polarized cell protrusive activity and intercalation that drives the convergent extension movements of vertebrate gastrulation [2], yet the underlying mechanism is unknown. We report that perturbing expression of Xenopus PCP genes, Strabismus (Xstbm), Frizzled (Xfz7), and Prickle (Xpk), disrupts radially polarized fibronectin fibril assembly on mesodermal tissue surfaces, mediolaterally polarized… CONTINUE READING