Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

@article{Mertens1996Plakophilins2A,
  title={Plakophilins 2a and 2b: constitutive proteins of dual location in the
 karyoplasm and the desmosomal plaque},
  author={Clarinda Mertens and Caecilia Kuhn and Werner Franke},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={135},
  pages={1009 - 1025}
}
Using antibodies and recombinant DNA techniques, we have identified plakophilin 2, a novel desmosomal plaque protein of M(r) 100,000 (estimated from SDS-PAGE), which is a member of the arm-repeat family of proteins and can occur in two splice forms (2a and 2b) because of the insertion of a 44 amino acid (aa)-encoding exon. In its aa sequence (837 and 881 aa, calculated pIs: 9.33 and 9.38, mol wts 92,750 and 97,410 kD), it is conspicuously related to the 80-kD plakophilin 1, with which it shares… CONTINUE READING
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