Plakophilin 3--a novel cell-type-specific desmosomal plaque protein.

  title={Plakophilin 3--a novel cell-type-specific desmosomal plaque protein.},
  author={Annette Wittrup Schmidt and Lutz Langbein and Silke Praetzel and Michaela Rode and H R Rackwitz and Werner Franke},
  journal={Differentiation; research in biological diversity},
  volume={64 5},
Desomosomes are cell-cell adhesion structures of epithelia and some non-epithelial tissues, such as heart muscle and the dendritic reticulum of lymph node follicles, which on their cytoplasmic side anchor intermediate filaments at the plasma membrane. Besides clusters of specific transmembrane glycoproteins of the cadherin family (desmogleins and desmocollins), they contain several desmosomal plaque proteins, such as desmoplakins, plakoglobin, and one or more plakophilins. Using recombinant DNA… CONTINUE READING