Plakoglobin is required for effective intermediate filament anchorage to desmosomes.

@article{Acehan2008PlakoglobinIR,
  title={Plakoglobin is required for effective intermediate filament anchorage to desmosomes.},
  author={Devrim Acehan and Christopher J. Petzold and Iwona Gumper and David D. Sabatini and Eliane J M{\"u}ller and Pamela Cowin and David L. Stokes},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 11},
  pages={2665-75}
}
Desmosomes are adhesive junctions that provide mechanical coupling between cells. Plakoglobin (PG) is a major component of the intracellular plaque that serves to connect transmembrane elements to the cytoskeleton. We have used electron tomography and immunolabeling to investigate the consequences of PG knockout on the molecular architecture of the intracellular plaque in cultured keratinocytes. Although knockout keratinocytes form substantial numbers of desmosome-like junctions and have a… CONTINUE READING

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