Placental viral infection sensitizes to endotoxin-induced pre-term labor: a double hit hypothesis.

@article{Cardenas2011PlacentalVI,
  title={Placental viral infection sensitizes to endotoxin-induced pre-term labor: a double hit hypothesis.},
  author={Ingrid Cardenas and G. P. Mor and Paulomi B. Aldo and Sabine M Lang and Paul R. Stabach and Andrew Clinton Sharp and Roberto Romero and Shali Mazaki-Tovi and Mariateresa Gervasi and Robert E. Means},
  journal={American journal of reproductive immunology},
  year={2011},
  volume={65 2},
  pages={
          110-7
        }
}
PROBLEM Among pregnant women, acquired viral infections with a concurrent bacterial infection is a detrimental factor associated to poor prognosis. We evaluate the effect of a viral infection that does not lead to pre-term labor on the response to low doses of lipopolysaccharide (LPS). Our objectives were (i) to characterize the effect of a viral infection concurrent with exposure to microbial products on pregnancy outcome and (ii) to characterize the placental and fetal immune responses to the… CONTINUE READING

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