Placental villous expression of TNFα and IL-10 and effect of oxygen tension in euploid early pregnancy failure.

@article{CallejaAgius2012PlacentalVE,
  title={Placental villous expression of TNFα and IL-10 and effect of oxygen tension in euploid early pregnancy failure.},
  author={Jean Calleja-Agius and Eric Jauniaux and Shanthi Muttukrishna},
  journal={American journal of reproductive immunology},
  year={2012},
  volume={67 6},
  pages={515-25}
}
PROBLEM The objective was to investigate placental inflammation in chromosomally normal miscarriages in vivo and in vitro. METHOD OF STUDY Chorionic villous tissue was collected from missed miscarriages and normal gestation-matched controls and cultured at 6 and 20% O(2) concentrations. Tissue was karyotyped. Flowcytometric bead arrays and real-time PCR were carried out for protein and gene expression studies. RESULTS The levels of TNFα and IL-10 were significantly (P < 0.005 and P < 0.05… CONTINUE READING
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