Placental type isoferritins in chronic liver diseases.

Abstract

Serum ferritin levels in chronic liver diseases were measured by an enzyme-linked immunosorbent assay (ELISA) using two monoclonal antibodies (McAb) against placental ferritin. One of the McAbs (CM-H9) recognizes a specific placental-like isoferritin (PLF) only, while the other McAb (CM-G8) recognizes an isoform (CF) common to human placenta, liver and spleen. The different diseases studied were primary biliary cirrhosis (PBC-14 patients), chronic active hepatitis (CAH-12 patients), alcoholic cirrhosis (AC-18 patients) and cryptogenic cirrhosis (CRY-26 patients). Increased levels of both isoferritine were found in all these liver disorders, with an overall incidence of 80% for CF and 40% for PLF. The mean level of CF was significantly above normal in PBC, AC and CRY and that of PLF in PBC and CRY. Circulating placental-type isoferritins have not been previously described in patients with liver disorders. Our findings indicate that elevation of serum ferritin in liver diseases is caused by different isoferritin components.

Statistics

05001000'95'97'99'01'03'05'07'09'11'13'15'17
Citations per Year

98 Citations

Semantic Scholar estimates that this publication has 98 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Konikoff1987PlacentalTI, title={Placental type isoferritins in chronic liver diseases.}, author={Fred Meir Konikoff and Yehuda Shoenfeld and D. A. Isenberg and Frances Theodor and Chaya Moroz}, journal={Hepato-gastroenterology}, year={1987}, volume={34 2}, pages={65-7} }