Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression.

@article{Lindegaard2006PlacentalTA,
  title={Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression.},
  author={Marie L S Lindegaard and Peter Damm and Elisabeth R Mathiesen and Lars Bo Nielsen},
  journal={Journal of lipid research},
  year={2006},
  volume={47 11},
  pages={2581-8}
}
Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid transport could be involved, the impact of maternal type 1 diabetes on molecular mechanisms for lipid transport in placenta is largely unknown. To examine whether maternal type 1 diabetes affects placental lipid metabolism, we measured lipids and mRNA expression of lipase-encoding genes in placentas from women… CONTINUE READING

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