Placental transfer of ochratoxin A and its cytotoxic effect on the mouse embryonic brain.

@article{Fukui1987PlacentalTO,
  title={Placental transfer of ochratoxin A and its cytotoxic effect on the mouse embryonic brain.},
  author={Yukata Fukui and Kazuki Hoshino and Yoichiro Kameyama and Tamotsu Yasui and C Toda and Hiroshi Nagano},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1987},
  volume={25 1},
  pages={17-24}
}
Pregnant ICR mice were given a single ip injection of 5 mg ochratoxin A/kg on day 11 or 13 of pregnancy. Concentrations of ochratoxin A in the maternal serum and tissues reached maximum levels within 2 hr of the injection and then decreased rapidly. The half-life of the toxin in serum was 28.7 hr on day 11 and 23.6 hr on day 13. On the other hand, the concentrations of ochratoxin A in the embryos were very low 2 hr after injection and then gradually increased up to 48 and 30 hr after injection… CONTINUE READING

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