Placental transfer of IgG subclasses in a Japanese population

  title={Placental transfer of IgG subclasses in a Japanese population},
  author={Shintaro Hashira and Shoko Okitsu‐Negishi and Kazuya Yoshino},
  journal={Pediatrics International},
Abstract Background: Maternal immunoglobulin G (IgG), transferred across the placenta to the fetus during intrauterine life, is an important component of the neonatal immunological defence mechanisms against infection. There is controversy with respect to differences in placental transfer of the different IgG subclasses, and no definite data are available on a Japanese population. Therefore, we investigated placental transfer of IgG subclasses in a Japanese population. 
Expression of FcRn receptor in placental tissue and its relationship with IgG levels in term and preterm newborns
This work investigated in a clinical setting the placental transmission of IgG antibodies in term and preterm newborns and found that preterm infants may not receive sufficient titers of protective antibodies.
[Placental immunoglobulin transfer].
  • É. Élefant
  • Medicine, Biology
    Bulletin de l'Academie nationale de medecine
  • 2012
Benefits and Risks of IgG Transplacental Transfer
The physiological mechanisms and benefits of transplacental transfer of maternal antibodies as well as pathological maternal situations where this system is hijacked are discussed, potentially leading to adverse neonatal outcomes.
In this studied Turkish population all four maternal IgG subclasses, IgG1 and IgG4 being more were transported across the placenta from mother to her fetus, relevant to both vaccination and disease surveillance in early infancy.
Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy
At birth, neonates are particularly vulnerable to infection and transplacental transfer of immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of life.
Update on Transplacental Transfer of IgG Subclasses: Impact of Maternal and Fetal Factors
This study evaluated concentrations and transplacental transfer ratios of the IgG subclasses in a healthy UK-based cohort of mother-cord pairs, and investigated associations with maternal, obstetric, and fetal factors, finding a strong association between maternal and cord IgG for all subclasses.
The transplacental transfer of IgG subclasses: influence of prematurity and low birthweight in the Gambian population
It is confirmed that prematurity and low birthweight are associated with impaired placental transfer of IgG1 and IgG2 subclasses in this Gambian population, which might explain the susceptibility of these newborns to certain polysaccharide-encapsulated organisms.
Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions.
2 human IgG3 antibodies with a hinge deletion and a C131S point mutation that eliminate complement activation and binding to all classical Fcγ receptors and to C1q while binding to FcRn is retained are reported on.
Deficit of IgG2 in HIV-positive pregnant women is responsible of inadequate IgG2 levels in their HIV-uninfected children in Malawi
Transplacental passage was reduced for all IgG subclasses and inversely correlated to high levels of maternal IgGs and to the degree of immunoactivation, which suggests that IgG2 neonatal levels mostly reflect the maternal deficit rather than a selective impairment of IgG 2 transfer.


The transfer of human IgG subclasses from mother to foetus.
The concentration of IgG subclasses was measured in matched pairs of maternal and cord serum by single radial immunodiffusion. IgG1, IgG3 and IgG4 were present in similar amounts in both the mothers
The placental transfer of IgG subclasses in human pregnancy.
It was found that there was a close linear relationship between gestational age and the placental transfer of IgG and each of its subclasses.
Gamma G subgroups in human fetal, cord, and maternal sera.
Maternal—Fetal Transport of Immunoglobulin G and Its Subclasses During the Third Trimester of Human Pregnancy
The maternal‐fetal transport of immunoglobulin G (IgG) during the third trimester of human pregnancy is determined and the importance of the second trimester for Down's syndrome is determined.
Correlation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigens.
The serum concentration of IgG-2 appears to provide a marker for predicting the ability to produce antibodies to polysaccharide, but not viral protein, antigens, in patients treated with both radiation and chemotherapy.
Role of antibody to native type III polysaccharide of group B Streptococcus in infant infection.
Earlier observations suggesting the correlation between low levels of type-specific antibody in serum and risk for systemic infection with type III strains of group B streptococci are extended are extended.