Placental transfer, lacteal transfer and plasma protein binding of gemcitabine.

Abstract

1. The placental transfer, lacteal transfer and plasma protein binding of gemcitabine have been studied in rat and dog after single intravenous administration of 10 mg/kg 14C-gemcitabine. 2. Radioactivity was distributed to the foetuses at 5 min after administration to rat on days 12 and 18 of gestation. The concentrations of radioactivity in the foetal… (More)

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@article{Esumi1994PlacentalTL, title={Placental transfer, lacteal transfer and plasma protein binding of gemcitabine.}, author={Yasuaki Esumi and Koichi Mitsugi and Hiroyuki Seki and Atsuyoshi Takao and Mineo Kawai}, journal={Xenobiotica; the fate of foreign compounds in biological systems}, year={1994}, volume={24 10}, pages={957-64} }