Placental transfer and developmental toxicity of 2,2',4,4',5,5'-hexabromobiphenyl in B6C3F1 mice.

@article{Welsch1985PlacentalTA,
  title={Placental transfer and developmental toxicity of 2,2',4,4',5,5'-hexabromobiphenyl in B6C3F1 mice.},
  author={Frank Welsch and Kevin T. Morgan},
  journal={Toxicology and applied pharmacology},
  year={1985},
  volume={81 3 Pt 1},
  pages={
          431-42
        }
}
The 2,2',4,4',5,5' congener of hexabromobiphenyl (HBB) is the major constituent (55%) of a polybrominated biphenyl mixture that accidentally entered the human food chain through livestock feed. The embryotoxicity of HBB in B6C3F1 conceptuses was examined by adding 0, 100, 300, 500, 750, or 1000 ppm of HBB to the diet of pregnant C57BL/6J mice impregnated by C3H males. The females consumed HBB feed from Gestation Day (gd) 6 through 15. Pregnancy rates of plug-positive mice were adversely… CONTINUE READING