Placental stress and pre-eclampsia: a revised view.

  title={Placental stress and pre-eclampsia: a revised view.},
  author={Christopher W. G. Redman and Ian I L Sargent},
  volume={30 Suppl A},
In pre-eclampsia, poor placentation causes both oxidative and endoplasmic reticulum stress of the placenta. It is believed placental hypoxia stimulates excessive production of soluble fms-like tyrosine kinase 1 (sFlt-1), which binds and deactivates circulating vascular endothelial growth factor (VEGF). When maternal endothelium is deprived of VEGF it becomes dysfunctional hence leading to the clinical syndrome of the mother. In this paper the previous claim that poor placentation may predispose… CONTINUE READING
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